Patented System

Rigenera® Technology

Rigenera® Technology is a patented mechanical system designed to obtain tissue-specific autologous micrografts through controlled mechanical disaggregation.

The process generates an injectable suspension of 80 µm micrografts (AMT), preserving high cell and biological component viability without enzymatic digestion or cell expansion.

Supported by 80+ peer-reviewed scientific publications, the AMT suspension is used across multiple regenerative medicine applications.

How The Technology Works

Three Core Elements

Rigenera® Technology operates through the synergy of three core elements.

Mytocel Rigeneracons® RS

Sterile class IIa disposable device containing calibrated microblades designed to mechanically disaggregate tissue samples.

N4SA Mytocel Machine

Motorized device providing controlled rotation to ensure standardized micrograft generation.

Transmisor: Sicurlid and Sicurstick

Transfers rotational mechanical energy from the N4SA Machine to the Rigeneracons.

The Science

The Science Behind Mytocel MSK

Auricular cartilage contains a perichondrium layer rich in mesenchymal progenitor cells and chondroblasts, which play a key role in cartilage regeneration and tissue homeostasis.

Mechanical disaggregation produces an AMT® suspension containing multiple biologically active elements:

Chondroprogenitor Cells

Chondrocytes

Extracellular Matrix Components

Signaling Factors (Cytokines, Growth Factors)

Chondrogenic Genes And Proteins

When introduced into the joint, these components contribute to:
1

Modulation of inflammatory signaling

2

Support of extracellular matrix homeostasis

3

Activation of endogenous regenerative pathways

This environment supports cartilage function and contributes to reduction of pain and stiffness in degenerative joint conditions.